For centuries, neem oil has been used as a natural, non-toxic pesticide to protect crops from insects. Now, dog parents are using neem oil to combat a variety of biting pests that plague our pups, such as fleas and mosquitoes. Azadirachtin, a component of neem oil, is accurately toxic to biting and chewing insects. Nimbin, another companent of neem oil is a potent anti-fungal with a long history of treating everything from ringworm to ear infection Humans & Mammals. Neem oil can also be used to soothe your dog’s itchy skin, thanks to the anti-inflammatory sterols and other triglycerides (fats) it contains, as well as the beneficial plant triterpenes.And because neem oil has natural antiseptic and antibacterial properties, it can be used to help heal skin infections in dogs. That’s even more important, now that antibiotic resistance is becoming so common.